Article
Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Pino Steve, Brehm Michael A, Covassin-Barberis Laurence, King Marie, Gott Bruce, Chase Thomas H, Wagner Jennifer, Burzenski Lisa, Foreman Oded, Greiner Dale L, Shultz Leonard D
Abstract excerpt
Immunodeficient mice have been used as recipients of human peripheral blood mononuclear cells (PBMC) for in vivo analyses of human xeno-graft-versus-host disease (GVHD). This xeno-GVHD model system in many ways mimics the human disease. The model system is established by intravenous or intraperitoneal injection of human PBMC or spleen cells into unconditioned or irradiated immunodeficient recipient mice....
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