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NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines.

Leukemia & lymphoma - 1 Jan 2015

Verner Jan, Trbusek Martin, Chovancova Jana, Jaskova Zuzana, Moulis Mojmir, Folber Frantisek, Halouzka Roman, Mayer Jiri, Pospisilova Sarka, Doubek Michael

Abstract excerpt

Xenograft models represent a promising tool to study the pathogenesis of hematological malignancies. To establish a reliable and appropriate in vivo model of aggressive human B-cell leukemia and lymphoma we xenotransplanted four p53-mutated cell lines and one ATM-mutated cell line into immunodeficient NOD/SCID IL2Rγ-null mice. The cell lines MEC-1, SU-DHL-4, JEKO-1, REC-1, and GRANTA-519 were transplanted...

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Identifiers

PMID: 25827173
DOI: 10.3109/10428194.2015.1034701

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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