Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.

Transplantation - 15 Oct 2003

Shultz Leonard D, Banuelos Scott, Lyons Bonnie, Samuels Rebecca, Burzenski Lisa, Gott Bruce, Lang Pamela, Leif Jean, Appel Michael, Rossini Aldo, Greiner Dale L

Abstract excerpt

BACKGROUND: A critical need exists for effective small-animal models that accept engraftment of human hematopoietic progenitor cells and mature lymphocytes. The purpose of this study was to determine the phenotypic effects of perforin (Pfp) deficiency on nonobese diabetic (NOD)-Rag1null mice and to evaluate the ability of NOD/LtSz-Rag1nullPfpnull recipients to support engraftment with human hematolymphoid cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Cell Count
Share to Blood Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Blood

Share to Immunoglobulins

Share to Lymphoid Tissue

Share to Perforin

Share to Pore Forming Cytotoxic Proteins

Share to Whole-Body Irradiation

Source

Identifiers

PMID: 14557749
DOI: 10.1097/01.TP.0000083041.44829.2C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.PMID 14557749Read ↗

Patterns of engraftment in different strains of immunodeficient mice reconstituted with human peripheral blood lymphocytes.Semantic proximity Read ↗

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftmentSemantic proximity Read ↗

Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rγnull mice display a T-effector memory phenotype.Semantic proximity Read ↗

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice.Semantic proximity Read ↗

Lack of acute xenogeneic graft‐ versus ‐host disease, but retention of T‐cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expressionSemantic proximity Read ↗

Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression ProfilesSemantic proximity Read ↗

Long-term engraftment of adult hematopoietic progenitors in a novel model of humanized miceSemantic proximity Read ↗

Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.Semantic proximity Read ↗

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD MiceSemantic proximity Read ↗

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cellsSemantic proximity Read ↗

Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesisSemantic proximity Read ↗

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.