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Article

Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Katano Ikumi, Takahashi Takeshi, Ito Ryoji, Kamisako Tsutomu, Mizusawa Takuma, Ka Yuyo, Ogura Tomoyuki, Suemizu Hiroshi, Kawakami Yutaka, Ito Mamoru

Abstract excerpt

We generated a severe immunodeficient NOD/Shi-scid-IL-2Rγ(null) (NOG) mouse substrain expressing the transgenic human IL-2 gene (NOG-IL-2 Tg). Upon transfer of human cord blood-derived hematopoietic stem cells (HSCs), CD3(-)CD56(high)CD16(+/-) cells developed unexpectedly, predominantly in the NOG-IL-2 Tg (hu-HSC NOG-IL-2 Tg). These cells expressed various NK receptors, including NKp30, NKp44, NKp46, NKG2D, and...

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Source

Identifiers

PMID: 25712215
DOI: 10.4049/jimmunol.1401323

Genes

NOG
CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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