Article
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.) - 1 Mar 2008
King Marie, Pearson Todd, Shultz Leonard D, Leif Jean, Bottino Rita, Trucco Massimo, Atkinson Mark A, Wasserfall Clive, Herold Kevan C, Woodland Robert T, Schmidt Madelyn R, Woda Bruce A, Thompson Michael J, Rossini Aldo A, Greiner Dale L
Abstract excerpt
Immunodeficient NOD-scid mice bearing a targeted mutation in the IL2 receptor common gamma chain (Il2rgamma(null)) readily engraft with human stem cells. Here we analyzed human peripheral blood mononuclear cells (PBMC) for their ability to engraft NOD-scid Il2rgamma(null) mice and established eng...
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