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Article

Interaction of avilamycin with ribosomes and resistance caused by mutations in 23S rRNA.

Antimicrobial agents and chemotherapy - 1 Nov 2002

Kofoed Christine B, Vester Birte

Abstract excerpt

The antibiotic growth promoter avilamycin inhibits protein synthesis by binding to bacterial ribosomes. Here the binding site is further characterized on Escherichia coli ribosomes. The drug interacts with domain V of 23S rRNA, giving a chemical footprint at nucleotides A2482 and A2534. Selection of avilamycin-resistant Halobacterium halobium cells revealed mutations in helix 89 of 23S rRNA. Furthermore,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12384333
DOI: 10.1128/AAC.46.11.3339-3342.2002
PMCID: PMC128742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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