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Article

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.

Molecular microbiology - 1 Jan 1999

Xiong L, Shah S, Mauvais P, Mankin A S

Abstract excerpt

Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide-binding site on the ribosome, a library of Escherichia coli clones, transformed with a plasmid carrying randomly mutagenized rRNA operon, was screened for mutants exhibiting resistance to the ketolide HMR3647. Sequencing of the plasmid isolated from one of the resistant clones and fragment exchange demonstrated that a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10027979
DOI: 10.1046/j.1365-2958.1999.01203.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.PMID 10027979Read ↗

Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA.Semantic proximity Read ↗

Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA.Semantic proximity Read ↗

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23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Semantic proximity Read ↗

Identification of a single base change in ribosomal RNA leading to erythromycin resistance.Semantic proximity Read ↗

Binding site of the bridged macrolides in the Escherichia coli ribosome.Semantic proximity Read ↗

Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance.Semantic proximity Read ↗

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.Semantic proximity Read ↗

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