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Article

Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction.

Antimicrobial agents and chemotherapy - 1 Dec 2005

Hobbie Sven N, Pfister Peter, Brüll Christian, Westhof Eric, Böttger Erik C

Abstract excerpt

The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis mc(2)155 SMR5 DeltarrnB with mutations in its single rRNA allele, rrnA. This genetic procedure...

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Identifiers

PMID: 16304180
DOI: 10.1128/AAC.49.12.5112-5118.2005
PMCID: PMC1315939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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