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Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes.

Cell transplantation - 1 Jan 2002

Kunieda Takemi, Kobayashi Naoya, Sakaguchi Masakiyo, Okitsu Teru, Totsugawa Toshinori, Watanabe Takamasa, Matsumura Toshihisa, Maruyama Masanobu, Noguchi Hirofumi, Takesue Michihiko, Shibata Norikuni, Ohmoto Kenji, Fujiwara Toshiyoshi, Yamamoto Shinichiro, Tanaka Noriaki

Abstract excerpt

We previously constructed an immortal human hepatocyte line NKNT-3 with a simian virus 40 T antigen (SV40T) to develop cell-based biological therapies. p21 is a molecule that regulates the transition from the G1 phase to the S phase of the cell cycle. Investigators have demonstrated that overexpression of p21 induces differentiation in various cell lines. In the current study we examined the effect of p21 on...

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PMID: 12382668

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TAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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