Article
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1993
Pfeifer A M, Cole K E, Smoot D T, Weston A, Groopman J D, Shields P G, Vignaud J M, Juillerat M, Lipsky M M, Trump B F
Abstract excerpt
Normal human liver tissue and cultured human hepatocytes are valuable models to study xenobiotic metabolism and toxicity, but they only have a limited in vitro life-span and are not readily available. This report describes the establishment of replicative cultures of human adult liver epithelial cells in serum-free medium. The longevity of three of these cultures, derived from different donors, was extended by...
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