Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.

Investigative ophthalmology & visual science - 1 May 1999

Offord E A, Sharif N A, Macé K, Tromvoukis Y, Spillare E A, Avanti O, Howe W E, Pfeifer A M

Abstract excerpt

PURPOSE: To develop a metabolically competent, human immortalized corneal epithelial cell line for use in toxicity and inflammation studies. METHODS: Primary corneal epithelial cells (P-CEPI) were immortalized by a recombinant simian virus (SV)40 T antigen retroviral vector defective for viral replication. The cells were grown in serum-free medium with the addition of bovine pituitary extract, cloned at passage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Epithelium, Corneal

Share to Growth Substances

Share to Keratitis

Share to Toxicity Tests

Source

Identifiers

PMID: 10235542

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies.PMID 10235542Read ↗

Comparative phenotypic and molecular characterization of primary, sv40-immortalized, and commercial human corneal keratocytes reveals a passage-dependent optimal window for in vitro applications.Semantic proximity Read ↗

Mucin Gene Expression in Immortalized Human Corneal–Limbal and Conjunctival Epithelial Cell LinesSemantic proximity Read ↗

Characterization of Growth and Differentiation in a Telomerase-Immortalized Human Corneal Epithelial Cell LineSemantic proximity Read ↗

Generation of Functional Immortalized Human Corneal Stromal Stem CellsSemantic proximity Read ↗

Functional Human Corneal Equivalents Constructed from Cell LinesSemantic proximity Read ↗

Culture, Immortalization, and Characterization of Human Meibomian Gland Epithelial CellsSemantic proximity Read ↗

A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapySemantic proximity Read ↗

Development and Characterization of In Vitro Human Oral Mucosal Equivalents Derived from Immortalized Oral KeratinocytesSemantic proximity Read ↗

Characterization of a Spontaneously Immortalized Cell Line (IOBA-NHC) from Normal Human ConjunctivaSemantic proximity Read ↗

An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cellsSemantic proximity Read ↗

Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).Semantic proximity Read ↗

Impact of Exosomes Released by Different Corneal Cell Types on the Wound Healing Properties of Human Corneal Epithelial CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.