Article
The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo.
Molecular cell - 1 Feb 2000
Deuring R, Fanti L, Armstrong J A, Sarte M, Papoulas O, Prestel M, Daubresse G, Verardo M, Moseley S L, Berloco M, Tsukiyama T, Wu C, Pimpinelli S, Tamkun J W
Abstract excerpt
Drosophila ISWI, a highly conserved member of the SWI2/SNF2 family of ATPases, is the catalytic subunit of three chromatin-remodeling complexes: NURF, CHRAC, and ACF. To clarify the biological functions of ISWI, we generated and characterized null and dominant-negative ISWI mutations. We found that ISWI mutations affect both cell viability and gene expression during Drosophila development. ISWI mutations also...
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