Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<scp>ATF4</scp> and N‐Myc coordinate glutamine metabolism in <i><scp>MYCN</scp></i>‐amplified neuroblastoma cells through <scp>ASCT2</scp> activation

21 Aug 2014

Abstract excerpt

Amplification of the MYCN gene in human neuroblastoma predicts poor prognosis and resistance to therapy. We previously showed that MYCN-amplified neuroblastoma cells constantly require large amounts of glutamine to support their unabated growth. However, the identity and regulation of the transporter(s) that capture glutamine in MYCN-amplified neuroblastoma cells and the clinical significance of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Neuroblastoma Research and Treatments
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25142020
DOI: 10.1002/path.4429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<scp>ATF4</scp> and N‐Myc coordinate glutamine metabolism in <i><scp>MYCN</scp></i>‐amplified neuroblastoma cells through <scp>ASCT2</scp> activationPMID 25142020Read ↗

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastomaSemantic proximity Read ↗

MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting NeuroblastomaSemantic proximity Read ↗

Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivationSemantic proximity Read ↗

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2Semantic proximity Read ↗

Amino Acid Metabolism Subtypes in Neuroblastoma Identifying Distinct Prognosis and Therapeutic Vulnerabilities.Semantic proximity Read ↗

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancerSemantic proximity Read ↗

NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence via the induction of ASCT2Semantic proximity Read ↗

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk NeuroblastomaSemantic proximity Read ↗

MYCN Amplifications and Metabolic Rewiring in NeuroblastomaSemantic proximity Read ↗

Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effectorSemantic proximity Read ↗

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastomaSemantic proximity Read ↗

Metabolic targeting of neuroblastoma, an updateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.