Article
Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.
Pflugers Archiv : European journal of physiology - 1 Feb 2016
Chan Kessara, Busque Stephanie M, Sailer Manuela, Stoeger Claudia, Bröer Stefan, Daniel Hannelore, Rubio-Aliaga Isabel, Wagner Carsten A
Abstract excerpt
Glutamine, the most abundant amino acid in mammals, is critical for cell and organ functions. Its metabolism depends on the ability of cells to take up or release glutamine by transporters located in the plasma membrane. Several solute carrier (SLC) families transport glutamine, but the SLC38 family has been thought to be mostly responsible for glutamine transport. We demonstrate that despite the large number of...
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