Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer.

Life sciences - 15 Feb 2022

Kim Suntae, Jeon Jang Su, Choi Yong June, Baek Ga Hee, Kim Sang Kyum, Kang Keon Wook

Abstract excerpt

AIMS: The purpose of this study was to evaluate the heterogeneities of glutamine metabolism in EGFR-TKI-resistant lung cancer cells and its potential as a therapeutic target. MAIN METHODS: Cell proliferation and cell cycle assays was performed by IncuCyte real-time analysis and flow cytometry, respectively. Tumor growth was assessed in xenografts implanted with HCC827 GR. An isotopologue analysis was conducted by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Thiadiazoles
Share to Carcinoma, Non-Small-Cell Lung
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Glutamine

Share to Protein Kinase Inhibitors

Share to Tandem Mass Spectrometry

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 34990648
DOI: 10.1016/j.lfs.2021.120274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer.PMID 34990648Read ↗

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)Semantic proximity Read ↗

Metabolic vulnerability of cisplatin‐resistant cancersSemantic proximity Read ↗

Stable isotope-resolved metabolomics analyses of metabolic phenotypes reveal variable glutamine metabolism in different patient-derived models of non-small cell lung cancer from a single patient.Semantic proximity Read ↗

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.Semantic proximity Read ↗

Glutamine deprivation counteracts hypoxia-induced chemoresistanceSemantic proximity Read ↗

Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapySemantic proximity Read ↗

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.Semantic proximity Read ↗

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growthSemantic proximity Read ↗

Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance.Semantic proximity Read ↗

Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cellsSemantic proximity Read ↗

Myc-induced glutaminolysis bypasses HIF-driven glycolysis in hypoxic small cell lung carcinoma cellsSemantic proximity Read ↗

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.