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Article

Pathogenesis of cleft palate in TGF-beta3 knockout mice.

Development (Cambridge, England) - 1 Sept 1999

Taya Y, O'Kane S, Ferguson M W

Abstract excerpt

We previously reported that mutation of the transforming growth factor-beta3 (TGF-beta3) gene caused cleft palate in homozygous null (-/-) mice. TGF-beta3 is normally expressed in the medial edge epithelial (MEE) cells of the palatal shelf. In the present study, we investigated the mechanisms by which TGF-beta3 deletions caused cleft palate in 129 x CF-1 mice. For organ culture, palatal shelves were dissected...

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Source

Identifiers

PMID: 10433915
DOI: 10.1242/dev.126.17.3869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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