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Article

Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure.

Biochemical and biophysical research communications - 18 Oct 2002

Vittitow Jason, Borrás Teresa

Abstract excerpt

Optineurin (optic neuropathy inducing protein; OPTN) was recently linked to 16.7% of families with primary open-angle glaucoma. The function of OPTN in the eye is not known, but is present in the trabecular meshwork, which is responsible for maintenance of intraocular pressure (IOP). To gain insight into the role of OPTN in the development of glaucoma we studied its expression in response to factors known to be...

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Source

Identifiers

PMID: 12379221
DOI: 10.1016/s0006-291x(02)02395-1

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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