Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.

doi:10.1167/iovs.03-1403

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Article

Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.

Investigative ophthalmology & visual science - 1 Dec 2004

Funayama Tomoyo, Ishikawa Karin, Ohtake Yuichiro, Tanino Tomihiko, Kurosaka Daijiro, Kimura Itaru, Suzuki Kotaro, Ideta Hidenao, Nakamoto Kenji, Yasuda Noriko, Fujimaki Takuro, Murakami Akira, Asaoka Ryo, Hotta Yoshihiro, Tanihara Hidenobu, Kanamoto Takashi, Mishima Hiromu, Fukuchi Takeo, Abe Haruki, Iwata Takeshi, Shimada Naoki, Kudoh Jun, Shimizu Nobuyoshi, Mashima Yukihiko

Abstract excerpt

PURPOSE: To investigate sequence variations in the optineurin (OPTN) gene and their association with TNF-alpha polymorphisms in Japanese patients with glaucoma. METHODS: The OPTN gene was analyzed in blood samples from 629 Japanese subjects. There were 194 patients with primary open-angle glaucoma (POAG), 217 with normal-tension glaucoma (NTG), and 218 with no eye disease (control subjects). The gene was screened...

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Identifiers

PMID: 15557444
DOI: 10.1167/iovs.03-1403

Genes

TNF
OPTN

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