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Article

Toward an integrative view of Optineurin functions

31 Jul 2012

Abstract excerpt

This review highlights recent advances in our understanding of the mechanisms of Optineurin (Optn) action and its implication in diseases. Optn has emerged as a key player regulating various physiological processes, including membrane trafficking, protein secretion, cell division and host defense against pathogens. Furthermore, there is growing evidence for an association of Optn mutations with human diseases...

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PMID: 22801549
DOI: 10.4161/cc.20946

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