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Article

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

1 Jan 2009

Abstract excerpt

AIMS: Optineurin is a gene (OPTN) associated with normal-tension glaucoma and primary open-angle glaucoma. The aim of our study is to understand the functions of the protein optineurin in retinal ganglion cells, and the modifications that come about in its functions when mutations occur in its sequence. METHODS: We have worked with the rat retinal ganglion cell line RGC5, as well as with some others such as HeLa...

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PMID: 19672125
DOI: 10.1159/000232400

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