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Article

A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α

27 Jan 2023

Abstract excerpt

Optineurin/OPTN polymorphism, M98K is associated with normal tension glaucoma in certain populations, and genetic evidence shows its interaction with tumour necrosis factor-alpha (TNFα) polymorphism in causing glaucoma. Endoplasmic reticulum (ER) stress is also associated with glaucoma. We hypothesized that M98K-OPTN may sensitize retinal ganglion cells to various types of stress. To test this hypothesis, stable...

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Share to Cellular transport and secretion
Share to Endoplasmic Reticulum Stress and Disease
Share to Glaucoma and retinal disorders

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PMID: 36705529
DOI: 10.1111/febs.16739

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