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Article

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma Susceptibility

27 Jun 2011

Abstract excerpt

MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG). The gene was identified as an up-regulated molecule in cultured trabecular meshwork (TM) cells after treatment with dexamethasone and was originally referred to as trabecular meshwork-inducible...

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Identifiers

PMID: 21709622
DOI: 10.3390/molecules16075402

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma SusceptibilityPMID 21709622Read ↗

The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Semantic proximity Read ↗

Cystatin a, a potential common link for mutant myocilin causative glaucoma.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Intracellular sequestration of hetero-oligomers formed by wild-type and glaucoma-causing myocilin mutants.Semantic proximity Read ↗

Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma.Semantic proximity Read ↗

Targeted Disruption of the Myocilin Gene (<i>Myoc</i>) Suggests that Human Glaucoma-Causing Mutations Are Gain of FunctionSemantic proximity Read ↗

Clinical phenotype of a Japanese family with primary open angle glaucoma caused by a Pro370Leu mutation in the MYOC/TIGR gene.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

MYOC/p.G367R mutation induces cell dysfunction of the trabecular meshwork and retina via impairment of the protein degradation mechanismSemantic proximity Read ↗

The genetics of open-angle glaucoma: the story of GLC1A and myocilin.Semantic proximity Read ↗

Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma.Semantic proximity Read ↗

Somatic Mutations within Myocilin due to Aging May Be a Potential Risk Factor for Glaucoma.Semantic proximity Read ↗

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