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Article

Adult-onset primary open-angle glaucoma caused by mutations in optineurin.

Science (New York, N.Y.) - 8 Feb 2002

Rezaie Tayebeh, Child Anne, Hitchings Roger, Brice Glen, Miller Lauri, Coca-Prados Miguel, Héon Elise, Krupin Theodore, Ritch Robert, Kreutzer Donald, Crick R Pitts, Sarfarazi Mansoor

Abstract excerpt

Primary open-angle glaucoma (POAG) affects 33 million individuals worldwide and is a leading cause of blindness. In a study of 54 families with autosomal dominantly inherited adult-onset POAG, we identified the causative gene on chromosome 10p14 and designated it OPTN (for "optineurin"). Sequence...

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Source

Identifiers

PMID: 11834836
DOI: 10.1126/science.1066901

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11834836-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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