Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predominance of CIN versus MSI in the development of rectal cancer at young age.

BMC cancer - 14 Oct 2002

Fernebro Eva, Halvarsson Britta, Baldetorp Bo, Nilbert Mef

Abstract excerpt

BACKGROUND: Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability (CIN) pathways. Colorectal cancers in patients under 50 years of age represent about 5% of the total number of tumors and have been associated with an increased frequency of MSI tumors. However, MSI and CIN may play different...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to beta Catenin
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Genes, ras

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Rectal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 12379157
DOI: 10.1186/1471-2407-2-25
PMCID: PMC130963

Genes

CTNNB1
KRAS
MSH2
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predominance of CIN versus MSI in the development of rectal cancer at young age.PMID 12379157Read ↗

Molecular Genetic Alterations and Clinical Features in Early-Onset Colorectal Carcinomas and Their Role for the Recognition of Hereditary Cancer SyndromesSemantic proximity Read ↗

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesis.Semantic proximity Read ↗

Microsatellite instability in gastrointestinal tract cancers: a brief update.Semantic proximity Read ↗

Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestineSemantic proximity Read ↗

Microsatellite instability in colorectal cancerSemantic proximity Read ↗

Can the histological type of colorectal cancer determine the carcinogenesis pathway?Semantic proximity Read ↗

Lynch Syndrome (HNPCC) and Microsatellite InstabilitySemantic proximity Read ↗

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal CancersSemantic proximity Read ↗

Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications.Semantic proximity Read ↗

Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines.Semantic proximity Read ↗

Microsatellite instability and survival in rectal cancer.Semantic proximity Read ↗

Pathways of colorectal carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.