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Article

Can the histological type of colorectal cancer determine the carcinogenesis pathway?

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jun 2015

Kołos Małgorzata, Wasążnik-Jędras Anna, Nasierowska-Guttmejer Anna

Abstract excerpt

Colorectal cancer (CRC) is the most common type of gastrointestinal cancer and has three major pathways of carcinogenesis. About 80% of genomic instability concerns chromosomal instability (CIN); the rest is connected with either microsatellite instability (MSI) or CpG island methylation. Some MSI-related cancers are associated with Lynch syndrome, whereas others are caused by sporadic, acquired hypermethylation...

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Source

Identifiers

PMID: 26247523
DOI: 10.5114/pjp.2015.53003

Genes

MLH1
BRAF
EGFR
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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