Article
Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure.
Molecular pharmacology - 1 Sept 2009
Dorn Gerald W, Liggett Stephen B
Abstract excerpt
One of the goals of pharmacogenomics is the use of genetic variants to predict an individual's response to treatment. Although numerous candidate and genome-wide associations have been made for cardiovascular response-outcomes, little is known about how a given polymorphism imposes the phenotype. Such mechanisms are important, because they tie the observed human response to specific signaling alterations and thus...
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