Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1.

Stem cells (Dayton, Ohio) - 1 Apr 2012

Li Yaochen, Hibbs Matthew Aaron, Gard Ashley Lauren, Shylo Natalia Aliakseeuna, Yun Kyuson

Abstract excerpt

The Notch pathway plays a pivotal role in regulating cell fate decisions in many stem cell systems. However, the full repertoire of Notch target genes in vivo and the mechanisms through which this pathway activity is integrated with other signaling pathways are largely unknown. Here, we report a transgenic mouse in which the activation of the Notch pathway massively expands the neural stem cell (NSC) pool in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Immunoprecipitation
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

Share to Neural Stem Cells

Share to Phosphoproteins

Share to Receptor, Notch1

Share to Wnt Proteins

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22232070
DOI: 10.1002/stem.1030
PMCID: PMC3734558

Genes

RBPJ
SHH
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1.PMID 22232070Read ↗

Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment.Semantic proximity Read ↗

Identifying regulators of neural stem cell fate and tumourigenesisSemantic proximity Read ↗

Distinct gene-selective roles for a network of core promoter factors in <i>Drosophila</i> neural stem cell identitySemantic proximity Read ↗

The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortexSemantic proximity Read ↗

Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation.Semantic proximity Read ↗

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain developmentSemantic proximity Read ↗

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical NeurogenesisSemantic proximity Read ↗

Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiationSemantic proximity Read ↗

Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.Semantic proximity Read ↗

Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes.Semantic proximity Read ↗

Dissecting Gene Regulatory Networks Governing Human Cortical Cell FateSemantic proximity Read ↗

The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.