Enhancer elements in the mouse Cyp1a2 gene for constitutive expression.

doi:10.1016/s0006-291x(02)02385-9

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Article

Enhancer elements in the mouse Cyp1a2 gene for constitutive expression.

Biochemical and biophysical research communications - 11 Oct 2002

Uchida Yo-ichi, Yano Aiko, Kumakura Shin-ichi, Sakuma Tsutomu, Nemoto Nobuo

Abstract excerpt

CYP1A2 is one of the major hepatic cytochrome P450s that is involved in the metabolism of many drugs, as well as in the activation of chemical carcinogens. To elucidate the transcriptional regulation of the constitutive expression of the mouse Cypla2 gene, the 4.8-kbp 5(')-flanking region of the gene was analyzed for transcriptional activity using a primary cultured mouse hepatocyte system. With 5(')- and...

Topics

Animals
Base Sequence
Cell Nucleus
Cells, Cultured
Cloning, Molecular
Cytochrome P-450 CYP1A2
Enhancer Elements, Genetic
Liver
Luciferases
Male
Mice
Mice, Inbred C57BL
Models, Genetic
Molecular Sequence Data
Mutation
Protein Binding
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 12372429
DOI: 10.1016/s0006-291x(02)02385-9

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