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Article

R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway.

Neuroscience letters - 31 Oct 2012

Lin Chenli, Liang Yinji, Zhu Huili, Zhang Jijun, Zhong Xueyun

Abstract excerpt

p53 mutation is associated with "gain-of-function" capabilities of human cancers. We aim to identify p53 mutations in human glioma cells and to explore the potential mechanism for mutant p53-promoted cellular growth. Whole genomic DNA was isolated from SWO-38, a human glioma cell line and amplified for the region of exons 5, 6, and 8 in p53 gene using polymerase chain reaction (PCR). By means of direct sequencing...

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Topics

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Share to Cell Line, Tumor
Share to Cell Proliferation
Share to Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to PTEN Phosphohydrolase

Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 22999923
DOI: 10.1016/j.neulet.2012.09.022

Genes

PTEN
AGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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