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Article

Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.

International journal of environmental research and public health - 12 Sept 2014

Yilmaz Ahmet, Mohamed Nehad, Patterson Kara A, Tang Yan, Shilo Konstantin, Villalona-Calero Miguel A, Davis Michael E, Zhou Xiaoping, Frankel Wendy, Otterson Gregory A, Beall Howard D, Zhao Weiqiang

Abstract excerpt

Cigarette smoking is one of the most significant public health issues and the most common environmental cause of preventable cancer deaths worldwide. EGFR (Epidermal Growth Factor Receptor)-targeted therapy has been used in the treatment of LC (lung cancer), mainly caused by the carcinogens in cigarette smoke, with variable success. Presence of mutations in the KRAS (Kirsten rat sarcoma viral oncogene homolog)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25222473
DOI: 10.3390/ijerph110909491
PMCID: PMC4199031

Genes

KRAS
NQO1
MET
DNMT1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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