Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.

doi:10.1097/00008571-199508000-00003

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Article

Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.

Pharmacogenetics - 1 Aug 1995

Rosvold E A, McGlynn K A, Lustbader E D, Buetow K H

Abstract excerpt

The enzyme NAD(P)H:quinone oxidoreductase (NQO1) catalyses bioreduction and bioactivation reactions. A mutation in the NQO1 gene had previously been demonstrated in a cancer cell line with reduced NQO1 activity. In this study, several regions of the NQO1 locus were examined for constitutional variation at the DNA level. The previously described mutation in exon 6 was detected by the single-strand conformation...

Topics

Alleles
Base Sequence
Case-Control Studies
Chromosome Mapping
Chromosomes, Human, Pair 16
DNA Primers
Exons
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Molecular Sequence Data

NAD(P)H Dehydrogenase (Quinone)

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8528266
DOI: 10.1097/00008571-199508000-00003

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8528266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.PMID 8528266Read ↗

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