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Article

Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.

Oncotarget - 30 Aug 2016

Lin Shan, Wei Junping, Wunderlich Mark, Chou Fu-Sheng, Mulloy James C

Abstract excerpt

Human CD34+ hematopoietic stem and progenitor cells (HSPC) expressing fusion protein AML1-ETO (AE), generated by the t(8;21)(q22;q22) rearrangement, manifest enhanced self-renewal and dysregulated differentiation without leukemic transformation, representing a pre-leukemia stage. Enabling replicative immortalization via telomerase reactivation is a crucial step in cancer development. However, AE expression alone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27509060
DOI: 10.18632/oncotarget.11093
PMCID: PMC5302887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation.PMID 27509060Read ↗

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