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Article

Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes.

Molecular microbiology - 1 Oct 2002

Michel Sonja, Ushinsky Sophia, Klebl Bert, Leberer Ekkehard, Thomas David, Whiteway Malcolm, Morschhäuser Joachim

Abstract excerpt

The yeast Candida albicans is the most important fungal pathogen of humans and a model organism for studying fungal virulence. Sequencing of the C. albicans genome will soon be completed, allowing systematic approaches to analyse gene function. However, techniques to define and characterize essential genes in this permanently diploid yeast are limited. We have developed an efficient method to create conditional...

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Share to Candida albicans
Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Nucleotidyltransferases

Share to Fungal Proteins

Share to Gene Deletion

Share to Gene Expression Regulation, Fungal

Share to Genes, Essential

Share to Transformation, Genetic

Source

Identifiers

PMID: 12366849
DOI: 10.1046/j.1365-2958.2002.03167.x

Genes

CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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