Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.

Nature genetics - 1 Jul 2010

Noble Suzanne M, French Sarah, Kohn Lisa A, Chen Victoria, Johnson Alexander D

Abstract excerpt

Candida albicans is the most common cause of serious fungal disease in humans. Creation of isogenic null mutants of this diploid organism, which requires sequential gene targeting, allows dissection of virulence mechanisms. Published analyses of such mutants show a near-perfect correlation between C. albicans pathogenicity and the ability to undergo a yeast-to-hypha morphological switch in vitro. However, most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Candida albicans
Share to Candidiasis
Share to Gene Library

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucosylceramides

Share to Hyphae

Share to Molecular Structure

Share to Morphogenesis

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 20543849
DOI: 10.1038/ng.605
PMCID: PMC2893244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.PMID 20543849Read ↗

Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.Semantic proximity Read ↗

Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes.Semantic proximity Read ↗

A Set of Diverse Genes Influence the Frequency of White-Opaque Switching in Candida albicans.Semantic proximity Read ↗

A Versatile Overexpression Strategy in the Pathogenic Yeast Candida albicans: Identification of Regulators of Morphogenesis and FitnessSemantic proximity Read ↗

A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families.Semantic proximity Read ↗

Recent advances on Candida albicans biology and virulenceSemantic proximity Read ↗

Candida Albicans: a molecular revolution built on lessons from budding yeast.Semantic proximity Read ↗

Gene Essentiality Analyzed by In Vivo Transposon Mutagenesis and Machine Learning in a Stable Haploid Isolate of Candida albicansSemantic proximity Read ↗

Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant CollectionSemantic proximity Read ↗

Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida albicans.Semantic proximity Read ↗

Comprehensive genetic analysis of adhesin proteins and their role in virulence of Candida albicans.Semantic proximity Read ↗

A data library of Candida albicans functional genomic screens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.