Article
Overexpression approaches to advance understanding of Candida albicans.
Molecular microbiology - 1 Mar 2022
Rai Laxmi Shanker, van Wijlick Lasse, Chauvel Murielle, d'Enfert Christophe, Legrand Mélanie, Bachellier-Bassi Sophie
Abstract excerpt
Candida albicans is an opportunistic fungal pathogen that is responsible for infections linked to high mortality. Loss-of-function approaches, taking advantage of gene knockouts or inducible down-regulation, have been successfully used in this species in order to understand gene function. However, overexpression of a gene provides an alternative, powerful tool to elucidate gene function and identify novel...
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