Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans.

doi:10.1128/EC.2.1.9-18.2003

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Article

Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans.

Eukaryotic cell - 1 Feb 2003

Bassilana Martine, Blyth James, Arkowitz Robert A

Abstract excerpt

Candida albicans, the most common human fungal pathogen, is particularly problematic for immunocompromised individuals. The reversible transition of this fungal pathogen to a filamentous form that invades host tissue is important for its virulence. Although different signaling pathways such as a mitogen-activated protein kinase and a protein kinase A cascade are critical for this morphological transition, the...

Topics

Animals
Candida albicans
Candidiasis
Cell Cycle Proteins
Cell Polarity
Cells, Cultured
Disease Models, Animal
Fungal Proteins
GTP Phosphohydrolase Activators
GTP Phosphohydrolases
GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanine Nucleotide Exchange Factors

Guanosine Diphosphate

Guanosine Triphosphate

Hyphae

Male

Mice

Mice, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 12582118
DOI: 10.1128/EC.2.1.9-18.2003
PMCID: PMC141177

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