Article
A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.
Mechanisms of development - 1 Nov 2002
Nakashima M, Tanese N, Ito M, Auerbach W, Bai C, Furukawa T, Toyono T, Akamine A, Joyner A L
Abstract excerpt
The Sonic hedgehog (Shh)-Gli signaling pathway regulates development of many organs, including teeth. We cloned a novel gene encoding a transcription factor that contains a zinc finger domain with highest homology to the Gli family of proteins (61-64% amino acid sequence identity) from incisor pulp. Consistent with this sequence conservation, gel mobility shift assays demonstrated that this new Gli homologous...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Binding Sites
- Blotting, Northern
- Cloning, Molecular
- DNA
- DNA, Complementary
- DNA-Binding Proteins
- Databases as Topic
- Dental Pulp