Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gli function is essential for motor neuron induction in zebrafish.

Developmental biology - 15 Jun 2005

Vanderlaan Gary, Tyurina Oksana V, Karlstrom Rolf O, Chandrasekhar Anand

Abstract excerpt

The Gli family of zinc-finger transcription factors mediates Hedgehog (Hh) signaling in all vertebrates. However, their roles in ventral neural tube patterning, in particular motor neuron induction, appear to have diverged across species. For instance, cranial motor neurons are essentially lost in zebrafish detour (gli1(-)) mutants, whereas motor neuron development is unaffected in mouse single gli and some...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Induction
Share to Hedgehog Proteins
Share to Motor Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Zebrafish Proteins

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 15890329
DOI: 10.1016/j.ydbio.2005.04.010
PMCID: PMC2219918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gli function is essential for motor neuron induction in zebrafish.PMID 15890329Read ↗

Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development.Semantic proximity Read ↗

The zebrafish detour gene is essential for cranial but not spinal motor neuron induction.Semantic proximity Read ↗

Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning.Semantic proximity Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.Semantic proximity Read ↗

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.Semantic proximity Read ↗

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.Semantic proximity Read ↗

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.Semantic proximity Read ↗

Genetics of neural development in zebrafish.Semantic proximity Read ↗

Shh and Gli3 activities are required for timely generation of motor neuron progenitors.Semantic proximity Read ↗

Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development.Semantic proximity Read ↗

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.