Article
Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development.
Development (Cambridge, England) - 1 Apr 2003
Karlstrom Rolf O, Tyurina Oksana V, Kawakami Atsushi, Nishioka Noriyuki, Talbot William S, Sasaki Hiroshi, Schier Alexander F
Abstract excerpt
Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse have shown that Gli1 is not essential for embryogenesis, whereas Gli2 acts as an activator of Hh target genes. In contrast, misexpression studies in Xenopus and cultured cells have suggested that Gli1 can act as an activator of Hh-regulated genes, whereas Gli2 might function as a repressor of a subset of Hh targets. To...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cloning, Molecular
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- In Situ Hybridization
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotides, Antisense
- Oncogene Proteins
- Phylogeny