Article
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E.
Developmental cell - 1 Sept 2002
Putkey Frances R, Cramer Thorsten, Morphew Mary K, Silk Alain D, Johnson Randall S, McIntosh J Richard, Cleveland Don W
Abstract excerpt
A selective disruption of the mouse CENP-E gene was generated to test how this kinetochore-associated, kinesin-like protein contributes to chromosome segregation. The removal of CENP-E in primary cells produced spindles in which some metaphase chromosomes lay juxtaposed to a spindle pole, despite the absence of microtubules stably bound to their kinetochores. Most CENP-E-free chromosomes moved to the spindle...
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