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An association study between Heme oxygenase-1 genetic variants and Parkinson's disease

24 Sept 2014

Abstract excerpt

The blood-brain barrier (BBB) supplies brain tissues with nutrients, filters harmful compounds from the brain back to the bloodstream, and plays a key role in iron homeostasis in the human brain. Disruptions of the BBB are associated with several neurodegenerative conditions including Parkinson's disease (PD). Oxidative stress, iron deposition and mitochondrial impaired function are considered as risk factors for...

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PMID: 25309329
DOI: 10.3389/fncel.2014.00298

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