Article
A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology.
Journal of cell science - 1 Nov 2002
Kuronita Toshio, Eskelinen Eeva-Liisa, Fujita Hideaki, Saftig Paul, Himeno Masaru, Tanaka Yoshitaka
Abstract excerpt
LGP85 (LIMP II) is a type III transmembrane glycoprotein that is located primarily in the limiting membranes of lysosomes and late endosomes. Despite being the abundant molecule of these compartments, whether LGP85 merely resides as one of the constituents of these membranes or plays a role in the regulation of endosome and lysosome biogenesis remains unclear. To elucidate these questions, we examined the effects...
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