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Article

Rab family proteins regulate the endosomal trafficking and function of RGS4.

The Journal of biological chemistry - 26 Jul 2013

Bastin Guillaume, Heximer Scott P

Abstract excerpt

RGS4, a heterotrimeric G-protein inhibitor, localizes to plasma membrane (PM) and endosomal compartments. Here, we examined Rab-mediated control of RGS4 internalization and recycling. Wild type and constitutively active Rab5 decreased RGS4 PM levels while increasing its endosomal targeting. Rab5, however, did not appreciably affect the PM localization or function of the M1 muscarinic receptor (M1R)/Gq signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23733193
DOI: 10.1074/jbc.M113.466888
PMCID: PMC3724640

Genes

RGS4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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