Article
Role of LAMP-2 in lysosome biogenesis and autophagy.
Molecular biology of the cell - 1 Sept 2002
Eskelinen Eeva-Liisa, Illert Anna Lena, Tanaka Yoshitaka, Schwarzmann Günter, Blanz Judith, Von Figura Kurt, Saftig Paul
Abstract excerpt
In LAMP-2-deficient mice autophagic vacuoles accumulate in many tissues, including liver, pancreas, muscle, and heart. Here we extend the phenotype analysis using cultured hepatocytes. In LAMP-2-deficient hepatocytes the half-life of both early and late autophagic vacuoles was prolonged as evaluated by quantitative electron microscopy. However, an endocytic tracer reached the autophagic vacuoles, indicating...
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