Article
Interleukin 1 and chronic rejection: possible genetic links in human heart allografts.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Jan 2002
Vamvakopoulos Joannis E, Taylor Craig J, Green Colin, McNeil Keith, Wallwork John, Goodman Reyna, Metcalf Su M
Abstract excerpt
Chronic rejection is a leading cause of graft loss in thoracic transplant recipients. Studies on the pathogenesis of chronic rejection have suggested a contributory role for certain cytokines and growth factors. The activity of these mediators is subject to genetic variation if a polymorphism alters expression, or function, of the ligand or its receptor. Here we have asked if certain cytokine and growth factor...
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