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Article

Genetic variability in the IL1RN gene and the balance between interleukin (IL)-1 receptor agonist and IL-1β in idiopathic pulmonary fibrosis.

Clinical and experimental immunology - 1 Dec 2011

Barlo N P, van Moorsel C H M, Korthagen N M, Heron M, Rijkers G T, Ruven H J T, van den Bosch J M M, Grutters J C

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive interstitial lung disease of unknown aetiology. Interleukin (IL)-1β plays an important role in inflammation and has been associated with fibrotic remodelling. We investigated the balance between IL-1β and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) and serum as well as the influence of genetic variability in the IL1B and...

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Identifiers

PMID: 22059992
DOI: 10.1111/j.1365-2249.2011.04468.x
PMCID: PMC3232382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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