Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro.

doi:10.1046/j.1365-3083.1998.00300.x

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Article

Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1beta production in vitro.

Scandinavian journal of immunology - 1 Mar 1998

Santtila S, Savinainen K, Hurme M

Abstract excerpt

The genes of the interleukin-1 (IL-1) complex code for three proteins: IL-1alpha, IL-1beta and the IL-1 receptor antagonist (IL-1RA). Each of these genes is polymorphic and there is increasing evidence that certain alleles are associated with increased susceptibility to a given disease of inflamm...

Topics

Alleles
Blood Donors
Cells, Cultured
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein
Interleukin-1
Leukocytes, Mononuclear
Sialoglycoproteins

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