Article
High frequency of RB1 mutations p16 positive early stage oropharyngeal carcinoma: A genomic and transcriptomic analysis.
Oral oncology - 1 Aug 2026
Brown Matthew H, Mendes William S, Song Yang, Shetty Amol C, Witek Matthew E, Mehra Ranee, Hatten Kyle M, Taylor Rodney J, Moyer Kelly F, Wolf Jeffrey S, Tyer Tiffani N, Steacy Katarina J, Eggleston Caitlin, Datnow Claudia, Gaykalova Daria A, Regine William F, Ren Lei, Tran Phuoc T, Ferris Matthew J, Molitoris Jason K
Abstract excerpt
BACKGROUND: The genomic landscape of p16 + oropharyngeal cancer (OPX), particularly in early-stage disease, remains limited. Better understandings of the differences between early and late-stage disease may improve elucidation of risk factors that warrant de-escalation. This analysis aims to substantially contribute to existing knowledge of the genomic landscape in an exclusively stage group I/II cohort....
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