Article
The CDKN2A (p16) gene and human cancer.
Molecular medicine (Cambridge, Mass.) - 1 Jan 1997
Foulkes W D, Flanders T Y, Pollock P M, Hayward N K
Abstract excerpt
CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome. In this review we tabulate the known mutations in this gene and discuss specific aspects, particularly with...
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