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Article

Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations.

Journal of the National Cancer Institute - 21 Jun 2000

Goldstein A M, Struewing J P, Chidambaram A, Fraser M C, Tucker M A

Abstract excerpt

BACKGROUND: Two genes have been implicated in the development of cutaneous malignant melanoma (CMM). CDK4 (the gene encoding cyclin-dependent kinase 4, an oncogene) has exhibited germline mutations found in only three melanoma-prone families to date. CDKN2A is a tumor suppressor gene that encodes p16 (which inhibits activity of the cyclin D1-CDK4 complex) with germline mutations detected in 10%-25% of...

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Identifiers

PMID: 10861313
DOI: 10.1093/jnci/92.12.1006

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CDK4

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